Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients
نویسندگان
چکیده
منابع مشابه
Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features
BACKGROUND A trough concentration of >20 mg/L is considered the optimal dosage of teicoplanin required to ensure early therapeutic effects against methicillin-resistant Staphylococcus aureus (MRSA) infections including those in patients who develop febrile neutropenia after chemotherapy. This study determines appropriate initial doses during the first 2 days of administration and evaluates the ...
متن کاملTeicoplanin pharmacokinetics in critically ill paediatric patients.
Twenty-one critically ill children aged between 7 days and 12 years were treated with teicoplanin (three loading dosages of 10 mg/kg at 12 h intervals, followed by a maintenance dosage of 10 mg/kg/day). Serum teicoplanin concentrations were monitored by HPLC. Mean concentrations in plasma 30 min after drug administration were 20 +/- 16.1 mg/L. The volume of distribution was 0.30 L/kg and the te...
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Blood lactate concentration (BLC) is widely used to guide resuscitation in critically ill patients [1]. Muscular microdialysis has previously been used illustrate the importance of the Na/K pump in hyperlactatemia in septic shock patients [2], with BLC reflecting metabolic changes rather than oxygen debt [3]. Microdialysis has now also been applied to intravascular continuous monitoring [4] (Ei...
متن کاملDevelopment of initial loading procedure for teicoplanin in critically ill patients with severe infections.
Methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in many hospitals. Infection with MRSA is more frequent in the intensive care unit (ICU) than in general wards. Therefore, appropriate treatments for MRSA infections will lead to good outcomes in the ICU. Teicoplanin is an anti-MRSA agent. Recently, it was recommended at a new target trough concentration of 15-30 µg/mL. However, ...
متن کاملROLE OF MAGNESIUM LOADING TEST IN DETECTING HYPOMAGNESEMIA IN CRITICALLY ILL PATIENTS
Magnesium (Mg) deficiency has not usually been considered in clinical practice due to lack of relevant blood tests and because the symptoms are often vague and nonspecific. Serum concentrations may not adequately reflect Mg status. Mg Loading Test (MLT) can provide infonnation on total body Mg stores. We prospectively studied 21 critically ill patients (10 male, 11 female) admitted to the I...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2019
ISSN: 1742-7835,1742-7843
DOI: 10.1111/bcpt.13338